Hmm. The flats I play are the same external gauges as the rounds I used to play: 45-60-80-105. Nothing needed at the nut, just a little burnishing to make sure everything was smooth and a little graphite (pencil lead) in the grooves, and everything should be fine.
Now, the bridge, with the change from tapered core to conventional strings, may need one or more (depending on how many strings in the set are tapered)saddle heights adjusted slightly, and intonation reset depending on how much "core stretch" your preferred strings have.
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