Bridge angle
I'd have to guess that bridge angle, like stated above, is what changed your sound. The bridge likes to tilt as you tune your strings--especially after you change your strings. If you don't have the bridge sitting firmly where it was originally set up (with a good setup), you're going to negatively impact the sound and feel.
I change strings nearly daily from solo to orchestral and back again. If I don't check the bridge assiduously every time I do that (and after I tune a few times), the sound and playability goes WAY down--even if the bridge is only a mm or two off. I left the tiny wax marks on the top of my bass, where my repairman put them, just in case I need to put the bridge back exactly where he knew it should be.
-Trevor
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