On the click, off the click.

[Bin Hire]

Originally Posted by Dave Martin

Use the metronome in whatever fashion helps your playing. Personally, I've never heard of anyone practicing with the click on 2 and 4, but whatever works...

The metronome on 2 and 4 is quite a common practice in my experience. It works like a back beat. Definitely harder at fast tempos to get going.